The pinacol rearrangement1 is a well-known reaction. It refers to the acid-catalyzed
transformation of 1, 2-diols to ketones or aldehydes by 1, 2-migration of a CÀC or CÀH bond …

The semi-pinacol rearrangement is fast becoming an extremely reliable reaction in organic
synthesis allowing the rapid construction of relatively complex stereodefined products in …

Convergent total syntheses of the potent cytotoxins (+)-tedanolide (1) and (+)-13-
deoxytedanolide (2) are described. The carbon framework of these compounds was …

Polypropionates are key subunits in structurally diverse polyketide natural products and
pharmaceuticals, rendering their synthesis an objective of high priority in synthetic organic …

Synthetic work toward the total synthesis of nitiol has culminated in the construction of two
epimeric hydroxylated derivatives, the 1, 22-dihydroxynitianes. Key stereodefining steps in …

An asymmetric synthesis of anti-aldol segments via a nonaldol route is described. The
strategy involves a highly diastereoselective synthesis of functionalized tetrahydrofuran …

Tedanolide, which was isolated by Schmitz in 1984 from the marine sponge Tedania ignis,
is a highly cytotoxic macrolide leading to strong growth inhibition of P338 tumor cells in …

Construction of Azaspirocyclic Ketones through α-Hydroxyiminium Ion or α-Siloxy Epoxide
Semipinacol Rearrangements | Organic Letters ACS ACS Publications C&EN CAS Find my …

The construction of 1-azaspirocyclic cycloalkanones using a siloxy− epoxide semipinacol
ring expansion process was examined. Functionalized 1-azaspiro [5.5] undecan-7-ones (1 …

A convergent synthesis of (+)-asteltoxin (1) has been achieved by the Horner− Emmons
olefination of bis (tetrahydrofuran) aldehyde 53 and α-pyrone phosphonate 5. A key step …