Label-and slide-free tissue histology using 3D epi-mode quantitative phase imaging and virtual hematoxylin and eosin staining

TM Abraham, PC Costa, C Filan, Z Guang, Z Zhang… - Optica, 2023 - opg.optica.org
Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining,
serves as the benchmark for disease diagnosis and comprehensive clinical assessment of …

Deep-learning-assisted microscopy with ultraviolet surface excitation for rapid slide-free histological imaging

Z Chen, W Yu, IHM Wong, TTW Wong - Biomedical Optics Express, 2021 - opg.optica.org
Histopathological examination of tissue sections is the gold standard for disease diagnosis.
However, the conventional histopathology workflow requires lengthy and laborious sample …

Generative Artificial Intelligence in Anatomic Pathology

V Brodsky, E Ullah, A Bychkov… - … of Pathology & …, 2025 - meridian.allenpress.com
Context.—Generative artificial intelligence (AI) has emerged as a transformative force in
various fields, including anatomic pathology, where it offers the potential to significantly …

Deep UV-excited fluorescence microscopy installed with CycleGAN-assisted image translation enhances precise detection of lymph node metastasis towards rapid …

J Sato, T Matsumoto, R Nakao, H Tanaka… - Scientific reports, 2023 - nature.com
Rapid and precise intraoperative diagnosing systems are required for improving surgical
outcomes and patient prognosis. Because of the poor quality and time-intensive process of …

Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

WY Park, J Yun, J Shin, BH Oh, G Yoon, SM Hong… - Elife, 2024 - elifesciences.org
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds
promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained …

Deep learning colorful ptychographic iterative engine lens-less diffraction microscopy

Y Bian, Y Jiang, J Wang, S Yang, W Deng… - Optics and Lasers in …, 2022 - Elsevier
The ptychographic iterative engine (PIE) is an algorithm for coherent lens-less diffraction
imaging. It facilitates the development of low-cost large field of view (FOV) lens-less …

Toward cell nuclei precision between OCT and H&E images translation using signal-to-noise ratio cycle-consistency

CH Liu, LW Fu, HH Chen, SL Huang - Computer Methods and Programs in …, 2023 - Elsevier
Medical image-to-image translation is often difficult and of limited effectiveness due to the
differences in image acquisition mechanisms and the diverse structure of biological tissues …

Mode-mapping qOBM microscopy to virtual hematoxylin and eosin (H&E) histology via deep learning

TM Abraham, PC Costa, CE Serafini… - … Optical Imaging III, 2022 - spiedigitallibrary.org
Quantitative oblique back-illumination microscopy (qOBM) is a novel microscopy technology
that enables real-time, label-free quantitative phase imaging (QPI) of thick and intact tissue …

Pilot study of fluorescence imitating brightfield imaging for rapid, slide‐free dermatopathology

TN Engel, TM Abraham, T Morningstar… - Journal of …, 2022 - Wiley Online Library
Background Fluorescence imitating brightfield imaging (FIBI) is a novel alternative
microscopy method that can image freshly excised, non‐sectioned tissue. We examine its …

[PDF][PDF] 基于深度学习的色彩迁移生物医学成像技术

卞殷旭, 邢涛, 邓伟杰, 鲜勤, 乔洪磊, 于钱… - 红外与激光 …, 2022 - researching.cn
传统病理学检测中, 由于复杂的染色流程和单一的观察形式等限制着病情的诊断速度,
而染色过程实质上是将颜色信息与形态特征关联, 效果等同于现代数字技术的生物医学图像的图 …