Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a
burden on global health and the economy. The enormously rising environmental changes …
burden on global health and the economy. The enormously rising environmental changes …
Nanomedicines modulate the tumor immune microenvironment for cancer therapy
Introduction In recent years, the evolution of immunotherapy as a means to trigger a robust
antitumor immune response has revolutionized cancer treatment. Despite its potential, the …
antitumor immune response has revolutionized cancer treatment. Despite its potential, the …
Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy
Epacadostat (EPA), the most advanced IDO1 inhibitor, in combination with PD-1 checkpoint
inhibitor, has failed in a recent Phase III clinical trial for treating metastatic melanoma. Here …
inhibitor, has failed in a recent Phase III clinical trial for treating metastatic melanoma. Here …
Targeting the tumor microenvironment by liposomal Epacadostat in combination with liposomal gp100 vaccine
Abstract Indoleamine-2, 3-dioxygenase (IDO1) pathway has vital role in cancer immune
escape and its upregulation leads to immunosuppressive environment which is associated …
escape and its upregulation leads to immunosuppressive environment which is associated …
[HTML][HTML] Design of a targeted dual drug delivery system for boosting the efficacy of photoimmunotherapy against melanoma proliferation and metastasis
Y Chen, S Xu, S Ren, J Zhang, J Xu, Y Song… - Journal of Advanced …, 2024 - Elsevier
Introduction The combination of a photosensitizer and indoleamine-2, 3 dioxygenase (IDO)
inhibitor provides a promising photoimmunotherapy (PIT) strategy for melanoma treatment …
inhibitor provides a promising photoimmunotherapy (PIT) strategy for melanoma treatment …
Chemo-immunotherapy by nanoliposomal epacadostat and docetaxel combination to IDO1 inhibition and tumor microenvironment suppression
R Khoshkhabar, M Yazdani, SH Alavizadeh… - International …, 2024 - Elsevier
The over-activation of tryptophan (Trp) metabolism to kynurenine (Kyn) catalyzed by
Indoleamine 2, 3-dioxygenase-1 (IDO1) enzyme, is one of the main metabolic pathways …
Indoleamine 2, 3-dioxygenase-1 (IDO1) enzyme, is one of the main metabolic pathways …
Role of Physicochemical Factors on the Efficacy and Safety of Lipid-Based Nanosystems as Potential Drug Carriers
M Aghajani, S Arbabi Bidgoli, K Tavakol - Nano, 2021 - World Scientific
The efficacy and safety are two challenging factors before trusting the lipid-based
Nanosystems (LBNs) for diagnostic and therapeutic purposes. The aim of this paper is to …
Nanosystems (LBNs) for diagnostic and therapeutic purposes. The aim of this paper is to …