Advantages and challenges of stem cell therapy for osteoarthritis

SJQ Loo, NK Wong - Biomedical reports, 2021 - spandidos-publications.com
Osteoarthritis (OA) is a degenerative disorder of the cartilage and is one of the leading
causes of disability, particularly amongst the elderly, wherein patients with advanced‑stage …

From mesenchymal stromal/stem cells to insulin-producing cells: progress and challenges

MA Ghoneim, AF Refaie, BL Elbassiouny… - Stem Cell Reviews and …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are an attractive option for cell therapy for type 1
diabetes mellitus (DM). These cells can be obtained from many sources, but bone marrow …

Bone marrow stem cell-derived β-cells: new issue for diabetes cell therapy

HA Aglan, SE Kotob, NS Mahmoud, MS Kishta… - Tissue and Cell, 2024 - Elsevier
This investigation aimed to establish the promising role of insulin-producing cells (IPCs)
growing from bone marrow-mesenchymal stem cells (BM-MSCs) in relieving hyperglycemia …

Regenerative and transplantation medicine: cellular therapy using adipose tissue-derived mesenchymal stromal cells for type 1 diabetes mellitus

H Takahashi, N Sakata, G Yoshimatsu… - Journal of clinical …, 2019 - mdpi.com
Type 1 diabetes mellitus (T1DM) is caused by the autoimmune targeting of pancreatic β-
cells, and, in the advanced stage, severe hypoinsulinemia due to islet destruction. In …

Osteoarthritis—The Role of Mesenchymal Stem Cells in Cartilage Regeneration

R Gherghel, LA Macovei, MA Burlui, A Cardoneanu… - Applied Sciences, 2023 - mdpi.com
Osteoarthritis (OA) is a condition that can cause substantial pain, loss of joint function, and a
decline in quality of life in patients. Numerous risk factors, including aging, genetics, and …

Comparison of the cytokine profile in mesenchymal stem cells from human adipose, umbilical cord, and placental tissues

K Zhang, F Li, B Yan, DJ Xiao, YS Wang… - Cellular …, 2021 - liebertpub.com
Human mesenchymal stem cells (MSCs) can be isolated from various tissues. However, the
cytokine profile in different MSC types remains unclear. In this study, MSCs were extracted …

Effective generation of functional pancreatic β cells from human-derived dental stem cells of apical papilla and bone-marrow-derived stem cells: a comparative study

D Abuarqoub, S Adwan, R Zaza, S Wehaibi, N Aslam… - Pharmaceuticals, 2023 - mdpi.com
Diabetes Mellitus Type 1 is an autoimmune disease that occurs due to the destruction of
insulin-producing cells (β cells), resulting in hyperglycemia. Therefore, diabetic patients …

[HTML][HTML] Tonsil-derived stem cells as a new source of adult stem cells

KA Cho, HJ Lee, H Jeong, M Kim, SY Jung… - World Journal of Stem …, 2019 - ncbi.nlm.nih.gov
Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil
tissue is a promising alternative source for the high-yield isolation of adult stem cells, and …

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice

MA Ghoneim, MM Gabr, AF Refaie… - Stem Cell Research & …, 2022 - Springer
Background The purpose of this study was to investigate allogenic immune responses
following the transplantation of insulin-producing cells (IPCs) differentiated from human …

Bioinformatics analysis and identification of circular RNAs promoting the osteogenic differentiation of human bone marrow mesenchymal stem cells on titanium treated …

S Zhu, Y Zhu, Z Wang, C Liang, N Cao, M Yan, F Gao… - PeerJ, 2020 - peerj.com
Background To analyze and identify the circular RNAs (circRNAs) involved in promoting the
osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs) on titanium by …