Phenibut: review and pharmacologic approaches to treating withdrawal

SR Penzak, M Bulloch - The Journal of Clinical Pharmacology, 2024 - Wiley Online Library
Abstract β‐Phenyl‐γ‐aminobutyric acid (phenibut) is an analog of the inhibitory
neurotransmitter γ‐aminobutyric acid (GABA) that was first synthesized in Russia in the early …

[HTML][HTML] Phenibutan—an Illegal Food Supplement With Psychotropic Effects and Health Risks

U Bonnet, N Scherbaum, A Schaper… - Deutsches Ärzteblatt …, 2024 - pmc.ncbi.nlm.nih.gov
Background Phenibut (β-phenyl-γ-aminobutyric acid) is an analog of the neurotransmitter
gamma-aminobutyric acid (GABA). Like abapentin and pregabalin, it inhibits α2-δ–subunits …

[HTML][HTML] Application of design of experiment for quantification of 71 new psychoactive substances in influent wastewater

D Nadarajan, J O'Brien, S Cresswell, B Kele… - Analytica Chimica …, 2024 - Elsevier
Background New psychoactive substances (NPS) are of public health concern due to their
sporadic proliferation and the dearth of information on toxicity when consumed. In addition to …

[HTML][HTML] The efficacy and mechanism of action of the Umei decoction in insomnia: A randomized active-controlled clinical trial

D Guo, J Liu, H Sun, N Zheng, Q Yang - Journal of Functional Foods, 2024 - Elsevier
Insomnia, affecting the quality of life of millions globally, necessitates urgent and effective
treatment strategies. This study conducted a randomized controlled trial to compare …

A Case of Phenibut Withdrawal Management and Detoxification Using Baclofen in the Outpatient Setting

E DiFiore, J Pittman - Case Reports in Psychiatry, 2024 - Wiley Online Library
Phenibut, a GABAB receptor agonist, has surged in popularity due to its nootropic and
anxiolytic effects. Despite not being FDA approved, it is accessible online due to its …

Phenibut: A drug with one too many “buts”

BJ Gurley, I Koturbash - Basic & Clinical Pharmacology & …, 2024 - Wiley Online Library
Phenibut is a gamma aminobutyric acid derivative with activity at γ‐aminobutyric acid
(GABA) B, A and β‐phenethylamine receptors. It was developed as a drug in the former …

[HTML][HTML] Purchasing “Nootropics” Online: Identification and Quantification of Ingredients in Phenibut-Containing Products

T Upmanis, E Sevostjanovs, L Zvejniece, H Kazoka… - Medicina, 2024 - mdpi.com
Background and Objectives: Phenibut is a central nervous system drug that is registered and
used in clinical practice as a prescription medication. In recent decades, the drug has …

Recognizing Withdrawal from Psychoactive Substances Purchased Online

CN Hollenhorst, B Schnipke - Journal of the Academy of Consultation …, 2025 - Elsevier
Discussion This case demonstrates severe withdrawal symptoms in a patient who attempted
phenibut detoxification at home. While there are other contributing factors for this patient …

Pharmacokinetics and Pharmacodynamics of Phenibut with Their Potential Dependence on Endogenous Hydrogen Sulfide: A Literature Review

O Kyrychenko, D Grebeniuk… - Asian Journal of …, 2024 - publish.journalgazett.co.in
Aims: The aim of the study was to analyze the current literature data on the
pharmacokinetics and pharmacodynamics of phenibut, as well as to evaluate their potential …

Global Trends and Disparities in Substance Use Disorders: Decades of Challenges amid Emerging Threats and the COVID-19 Impact (1990-2021)

T Yu, M Wang, J Zheng, S Guan, J Chen - 2024 - researchsquare.com
Aims To provide a comprehensive analysis of the global epidemiology of substance use
disorders (SUDs) from 1990 to 2021, highlighting trends, disparities, and public health …