We generated four HIV-1 cultures that are resistant to a peptide fusion inhibitor
corresponding to the first heptad repeat of gp41 in order to study mechanisms of resistance …

BACKGROUND: Entry inhibitors are a class of antiretroviral (ARV) drugs that prevent HIV
replication by blocking viral entry into the host cell. The investigation of naturally occurring …

Entry inhibitor is a new class of drugs that target the viral envelope protein. This region is
variable; hence resistance to these drugs may be present before treatment. The aim of this …

We assessed the natural genotypic and phenotypic susceptibilities to enfuvirtide of 171 HIV
group O (HIV-O) samples and 29 strains, respectively. The N42D resistance-associated …

The selective pressure of antiretroviral drugs (ARVs) targeting HIV‐1 pol can promote drug
resistance mutations in other genomic regions, such as env. Drug resistance among women …

Background Human immunodeficiency virus (HIV) increasing molecular diversity and
emergence of drug resistant mutants remain a major concern in China. Enfuvirtide (ENF/T …

Objective: To evaluate the polymorphisms and resistance mutations in gp41 HR1 region of
HIV-1. Methods: The study included 28 HIV-positive patients undergoing enfuvirtide (ENF) …

HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of
gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we …

Mother-to-child transmission (MTCT) through breastfeeding remains a major source of
pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations …

Here we review the prevalence of HIV-1 primary drug resistance in Latin America and
Caribbean using meta-analysis as well as time-series modeling. We also discuss whether …