Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Free-living amoebae are protists frequently found in water and soils. They feed on other
microorganisms, mainly bacteria, and digest them through phagocytosis. It is accepted that …

Acanthamoeba keratitis (AK) is a severe cause of infectious keratitis and represents a
significant clinical challenge. Recent literature regarding AK epidemiology, diagnosis …

Although major strides have been made in developing and testing various anti-
acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health …

Infectious diseases are the leading cause of morbidity and mortality, killing more than 15
million people worldwide. This is despite our advances in antimicrobial chemotherapy and …

Acanthamoeba, a genus that contains at least 24 species of free-living protozoa, is
ubiquitous in nature. Successful treatment of Acanthamoeba infections is always very …

Pathogenic free-living amoebae affecting the central nervous system are known to cause
granulomatous amoebic encephalitis (GAE) or primary amoebic meningoencephalitis …

Acanthamoeba keratitis is a sight-threatening infectious disease. Resistance of the cystic
form of the protozoan to biocides and the potential toxicity of chemical compounds to corneal …

Current treatments for Acanthamoeba keratitis rely on a combination of chlorhexidine
gluconate, propamidine isethionate, and polyhexamethylene biguanide. These disinfectants …

Today's microbial infections' resistance to approved drugs, the emergence of new infectious
diseases and lack of vaccines, create a huge threat to human health. Thus, there is an …