Abstract Heat shock protein 90 (HSP90), a highly and unique chaperone, presents as a
double-edged sword. It plays an essential role in many physiological and pathological …

Inhibiting individual histone deacetylase (HDAC) is emerging as well-tolerated anticancer
strategy compared with pan-HDAC inhibitors. Through preclinical studies, we demonstrated …

Tubulins play crucial roles in cell division, intracellular traffic, and cell shape. Tubulin
concentration is autoregulated by feedback control of messenger RNA (mRNA) degradation …

The MYC oncogenic transcription factor is acetylated by the p300 and GCN5 histone
acetyltransferases. The significance of MYC acetylation and the functions of specific …

Through a targeted knockdown (KD) screen of chromatin regulatory genes, we identified the
EP400 complex components EPC1 and EPC2 as critical oncogenic cofactors in acute …

Background The apparent lack of additional missense mutations data on mixed-phenotype
leukemia is noteworthy. Single amino acid substitution by these non-synonymous single …

Background Neuroblastoma is the most common extracranial solid tumor of childhood. The
heterogeneous microenvironment of solid tumors contains hypoxic regions associated with …

Background Cardiomyocyte injury is a typical feature in cardiovascular diseases. Changes
in cardiomyocytes strongly affect the progression of cardiovascular diseases. This work …

Acute myeloid leukemia (AML) is a cancer that affects the myeloid line of blood cells. Acute
lymphoid leukemia (ALL) is a type of leukemia that targets the lymphoid line of blood cells …

The maturation of RNA is mediated by the coordinated actions of RNA-binding proteins
through post-transcriptional pre-mRNA processing. This process is a central regulatory …