Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …

TRAIL (tumor-necrosis factor related apoptosis-inducing ligand, CD253) and its death
receptors TRAIL-R1 and TRAIL-R2 selectively trigger the apoptotic cell death in tumor cells …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

Highlights•Immunotherapy and nanomedicine are continuously attractive research
areas.•Gut microbiota and probiotics are emerging hotspots in cancer-bacteriotherapy.•East …

Despite decades of research, cancer continues to be a major global health concern. The
human mouth appears to be a multiplicity of local environments communicating with other …

Live attenuated bacteria have been used as target vehicles for genetic therapy of malignant
carcinoma because they can be reprogrammed by following simple genetic rules and have …

Motile bacteria can overcome the penetration limitations of cancer chemotherapeutics
because they can actively migrate into solid tumors. Although several genera of bacteria …

TNF-related apoptosis-inducing ligand (TRAIL) selectively induces the apoptosis pathway in
tumor cells leading to tumor cell death. Because TRAIL induction can kill tumor cells, cancer …

Protein drugs are a unique and versatile class of biotherapeutics that have not only high
biological activity but also superb specificity. This rapidly evolving biotechnology has …