Molecular docking has been widely employed as a fast and inexpensive technique in the
past decades, both in academic and industrial settings. Although this discipline has now had …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

In an attempt to extend recent studies showing that some clinically evaluated histamine H3
receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we …

Butyrylcholinesterase (BChE) is a promising target for the treatment of later stage cognitive
decline in Alzheimer's disease. A set of pseudo-irreversible BChE inhibitors with high …

The enzyme butyrylcholinesterase (BChE) and the human cannabinoid receptor 2 (h CB2R)
represent promising targets for pharmacotherapy in the later stages of Alzheimer's disease …

Contilisant, a permeable, antioxidant, and neuroprotectant agent, showing high nM affinity at
H3R and excellent inhibition of the monoamine oxidases and cholinesterases, is an affine …

Abstract Development of multitargeted ligands have demonstrated remarkable efficiency as
potential therapeutics for Alzheimer's disease (AD). Herein, we reported a new series of …

The present study reports adsorption mechanism of histamine on the surfaces of pure, B-or
Si-doped fullerenes. The adsorption of histamine on pure and doped fullerenes has been …