Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases

JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …

Transforming vaccinology

R Rappuoli, G Alter, B Pulendran - Cell, 2024 - cell.com
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global
consciousness, emphasizing the vital role of vaccines as transformative public health tools …

An aluminum hydroxide: CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice

E Nanishi, F Borriello, TR O'Meara… - Science translational …, 2021 - science.org
Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …

A novel therapeutic vaccine based on graphene oxide nanocomposite for tumor immunotherapy

L Zhang, L Xu, Y Wang, J Liu, G Tan, F Huang… - Chinese Chemical …, 2022 - Elsevier
With an intensive understanding of the mechanism of immune system, developing a
therapeutic tumor vaccine is one of the most perspective strategy of cancer immunotherapy …

Clinical applications of single-stranded oligonucleotides: current landscape of approved and in-development therapeutics

J Scharner, I Aznarez - Molecular Therapy, 2021 - cell.com
Single-stranded oligonucleotides have been explored as a therapeutic modality for more
than 20 years. Only during the last 5 years have single-stranded oligonucleotides become a …

Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …

Understanding nucleic acid sensing and its therapeutic applications

LZ Kong, SM Kim, C Wang, SY Lee, SC Oh… - … & Molecular Medicine, 2023 - nature.com
Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

Recent Developments in Nanoparticle‐Based Photo‐Immunotherapy for Cancer Treatment

Z Guo, AT Zhu, RH Fang, L Zhang - Small methods, 2023 - Wiley Online Library
Phototherapy is an emerging approach for cancer treatment that is effective at controlling the
growth of primary tumors. In the presence of light irradiation, photothermal and …

The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions

WJ Pichler - Allergy, 2022 - Wiley Online Library
Drug hypersensitivity reactions (DHR) are heterogeneous and unusual immune reactions
with rather unique clinical presentations. Accumulating evidence indicates that certain non …

Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection

J Zang, Y Zhu, Y Zhou, C Gu, Y Yi, S Wang, S Xu, G Hu… - Cell Discovery, 2021 - nature.com
Massive production of efficacious SARS-CoV-2 vaccines is essential for controlling the
ongoing COVID-19 pandemic. We report here the preclinical development of yeast …