Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity and increased neuronal responsiveness in central pain pathways after painful …

Atopic dermatitis (AD) is a public health concern and is increasing in prevalence in urban
areas. Recent advances in sequencing technology have demonstrated that the development …

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Pattern recognition receptors (PRRs) are part of the innate immune response and were
originally discovered for their role in recognizing pathogens by ligating specific pathogen …

Sensory neurons are activated by physical and chemical stimuli, eliciting sensations such as
temperature, touch, pain, and itch. From an evolutionary perspective, sensing danger is …

For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation,
represents a cardinal feature of neuropathic pain. Blockade or ablation of high-threshold …

Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms
underlying these symptoms are unknown. We report that bile acids, which are elevated in …

Itch is described as an irritating sensation that triggers a desire to scratch. However, this
definition hardly seems fitting for the millions of people who suffer from intractable itch …