All retroviruses, including HIV-1, display species-specific patterns of infection. The impaired
growth of these retroviruses in foreign and sometimes even in their natural hosts often stems …

There are currently 25 drugs belonging to 6 different inhibitor classes approved for the
treatment of human immunodeficiency virus (HIV) infection. However, new anti-HIV agents …

Human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) inhibit replication of
Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host …

Background Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that
methylates arginine residues on histones and transcription factors. In addition, PRMT6 …

Many proteins do not exist in a single rigid conformation. Protein motions, or dynamics, exist
and in many cases are important for protein function. The analysis of protein dynamics relies …

APOBEC3G (A3G) is a deoxycytidine deaminase active on ssDNA substrates. In HIV
infected cells A3G interacted with reverse transcription complexes where its activity as a …

Highlights•Insight into new strategies in HIV therapy.•Targeting protein–protein interactions
in HIV.•Targeting cellular cofactors in HIV.Two novel approaches for the development of new …

The viral infectivity factor (Vif) is essential for the productive infection and dissemination of
HIV-1 in non-permissive cells that involve most natural HIV-1 target cells. Vif counteracts the …

Human immunodeficiency virus-1 (HIV-1) has evolved a cunning mechanism to circumvent
the antiviral activity of the APOBEC3 family of host cell enzymes. HIV-1 Vif [viral (also called …

Abstract The Human Immunodeficiency Virus (HIV) is the cause of the AIDS disease. To
date, more than 30 million people worldwide are infected with HIV-1, which causes two …