Rethinking food reward

IE de Araujo, M Schatzker… - Annual review of …, 2020 - annualreviews.org
The conscious perception of the hedonic sensory properties of caloric foods is commonly
believed to guide our dietary choices. Current and traditional models implicate the …

Learning of food preferences: mechanisms and implications for obesity & metabolic diseases

HR Berthoud, CD Morrison, K Ackroff… - International Journal of …, 2021 - nature.com
Omnivores, including rodents and humans, compose their diets from a wide variety of
potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to …

Hypothalamic detection of macronutrients via multiple gut-brain pathways

N Goldstein, AD McKnight, JRE Carty, M Arnold… - Cell metabolism, 2021 - cell.com
Food intake is tightly regulated by complex and coordinated gut-brain interactions. Nutrients
rapidly modulate activity in key populations of hypothalamic neurons that regulate food …

Gut-brain communication and obesity: understanding functions of the vagus nerve

HR Berthoud, VL Albaugh… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Given the crucial role of the gastrointestinal tract and associated organs in handling nutrient
assimilation and metabolism, it has long been known that its communication with the brain is …

The neural basis of sugar preference

WW Liu, DV Bohórquez - Nature Reviews Neuroscience, 2022 - nature.com
When it comes to food, one tempting substance is sugar. Although sweetness is detected by
the tongue, the desire to consume sugar arises from the gut. Even when sweet taste is …

Roles for the gut microbiota in regulating neuronal feeding circuits

BY Kristie, EY Hsiao - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The gut microbiota has the capacity to affect host appetite via intestinal satiety pathways, as
well as complex feeding behaviors. In this Review, we highlight recent evidence that the gut …

The impact of caloric availability on eating behavior and ultra-processed food reward

AL Kelly, ME Baugh, ME Oster, AG DiFeliceantonio - Appetite, 2022 - Elsevier
The food environment has changed rapidly and dramatically in the last 50 years. While
industrial food processing has increased the safety and stability of the food supply, a rapid …

The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity

R Gutierrez, E Fonseca, SA Simon - Cellular and Molecular Life Sciences, 2020 - Springer
Throughout the animal kingdom sucrose is one of the most palatable and preferred tastants.
From an evolutionary perspective, this is not surprising as it is a primary source of energy …

Sweet taste is complex: signaling cascades and circuits involved in sweet sensation

E von Molitor, K Riedel, M Krohn, M Hafner… - Frontiers in Human …, 2021 - frontiersin.org
Sweetness is the preferred taste of humans and many animals, likely because sugars are a
primary source of energy. In many mammals, sweet compounds are sensed in the tongue by …

Postingestive modulation of food seeking depends on vagus-mediated dopamine neuron activity

AB Fernandes, JA da Silva, J Almeida, G Cui… - Neuron, 2020 - cell.com
Postingestive nutrient sensing can induce food preferences. However, much less is known
about the ability of postingestive signals to modulate food-seeking behaviors. Here we …