Complex barriers separate immune-privileged tissues from the circulation. Here, we propose
that cell entry to immune-privileged sites through barriers composed of tight junction …

Dendritic cells (DCs) are central in the orchestration of the various forms of immunity and
tolerance. Their immunoregulatory role mainly relies on the ligation of specific receptors that …

Most higher animals require sight for survival, yet even minor distortions of the visual axis
can cause blindness. For this reason, intraocular inflammation is incompatible with good …

Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

Certain cellular components of the eye, such as neural retina, are unable to regenerate and
replicate after destructive inflammation. Ocular immune privilege provides the eye with …

It has been over 60 years since the phrase immune privilege was used by Sir Peter
Medawar to describe the lack of an immune response against allografts placed into the …

Autoimmune uveitis is a blinding disease presenting with autoantibodies against eye-
specific proteins as well as autoagressive T cells invading and attacking the immune …

purpose. To extensively characterize the complex network of cytokines present in uveitis
aqueous humor (AqH), and the relationships between cytokines and the cellular infiltrate …

Intraocular inflammatory diseases are a common cause of severe visual impairment and
blindness. In this study, we investigated the immunoregulatory role of galectin-1 (Gal-1), an …

The ocular tissue microenvironment is immune privileged and uses several mechanisms of
immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier …