Key considerations to improve the normalization, interpretation and reproducibility of morbidity data in mammalian models of viral disease

JA Belser, TJ Kieran, ZA Mitchell… - Disease Models & …, 2024 - journals.biologists.com
Viral pathogenesis and therapeutic screening studies that utilize small mammalian models
rely on the accurate quantification and interpretation of morbidity measurements, such as …

Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses

S Chiba, M Hatta, D Pattinson, A Yasuhara… - Vaccine, 2023 - Elsevier
Mutations accumulate in influenza A virus proteins, especially in the main epitopes on the
virus surface glycoprotein hemagglutinin (HA). For influenza A (H3N2) viruses, in particular …

Intranasal treatment of ferrets with inert bacterial spores reduces disease caused by a challenging H7N9 avian influenza virus

J James, SM Meyer, HA Hong, C Dang, HTY Linh… - Vaccines, 2022 - mdpi.com
Background: Influenza is a respiratory infection that continues to present a major threat to
human health, with~ 500,000 deaths/year. Continued circulation of epidemic subtypes in …

Genetic and pathogenic potential of highly pathogenic avian influenza H5N8 viruses from live bird markets in Egypt in avian and mammalian models

Y Moatasim, BE Aboulhoda, M Gomaa, A El Taweel… - Plos one, 2024 - journals.plos.org
Since its first isolation from migratory birds in Egypt in 2016, highly pathogenic avian
influenza (HPAI) H5N8 has caused several outbreaks among domestic poultry in various …

Infection with seasonal H1N1 influenza results in comparable disease kinetics and host immune responses in ferrets and golden Syrian hamsters

J Paterson, KA Ryan, D Morley, NJ Jones, P Yeates… - Pathogens, 2023 - mdpi.com
Animal models of influenza are important in preclinical research for the study of influenza
infection and the assessment of vaccines, drugs and therapeutics. Here, we show that …

[HTML][HTML] A recombinant N2 neuraminidase-based CpG 1018® adjuvanted vaccine provides protection against challenge with heterologous influenza viruses in mice …

I Hoxie, K Vasilev, JJ Clark, K Bushfield, B Francis… - Vaccine, 2024 - Elsevier
Recombinant influenza virus neuraminidase (NA) is a promising broadly protective influenza
vaccine candidate. However, the recombinant protein alone is not sufficient to induce …

[HTML][HTML] Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza …

E Stepanova, V Matyushenko, D Mezhenskaya… - Vaccines, 2024 - pmc.ncbi.nlm.nih.gov
Background/Objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with
similar seasonality, and both pathogens are characterized by a high mutational rate which …

Single immunization with an influenza hemagglutinin nanoparticle‐based vaccine elicits durable protective immunity

S Chiba, T Maemura, K Loeffler, SJ Frey… - Bioengineering & …, 2024 - Wiley Online Library
Vaccination is the most effective strategy to combat influenza. Ideally, potent and persistent
vaccine effects would be induced with a single vaccine dose. Here, we designed a virus‐like …

Virulence and tissue tropism of different epidemiologically significant SARS-CoV-2 variants for golden Syrian hamsters

AV Gracheva, AO Drokov, DI Smirnova… - Journal of …, 2024 - microbiol.crie.ru
Virulence and tissue tropism of different epidemiologically significant SARS-CoV-2 variants for
golden Syrian hamsters - Gracheva - Journal of microbiology, epidemiology and …