Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

Summary The UN Sustainable Development Goals provide a historic opportunity to
implement interventions, at scale, to promote early childhood development. Although the …

In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …

Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …

Childhood trauma confers higher risk of adulthood physical and mental illness; however, the
biological mechanism mediating this association remains largely unknown. Recent research …

Post-traumatic stress disorder (PTSD) occurs in 5–10% of the population and is twice as
common in women as in men. Although trauma exposure is the precipitating event for PTSD …

PTSD is characterized by the persistence of intense reactions to reminders of a traumatic
event, altered mood, a sense of imminent threat, disturbed sleep, and hypervigilance …

The literature on managerial style posits a linear relation between a chief executive officer's
(CEOs) past experiences and firm risk. We show that there is a nonmonotonic relation …

The risk for major depression is both genetically and environmentally determined. It has
been proposed that epigenetic mechanisms could mediate the lasting increases in …