Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Cell death is central to development, organismal homeostasis, and immune responses. The
cell death field has experienced tremendous progress by delineating the molecular …

Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD)
such as Crohn's disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes …

The majority of colorectal cancer patients are not responsive to immune checkpoint
blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and …

Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or …

Interferon-gamma (IFNG) has long been implicated as a central orchestrator of antitumor
immune responses in the elimination stage of the immunoediting paradigm. However …

Psoriasis is a common, immune-mediated genetic disorder of the skin and is associated with
arthritis in approximately 30% of cases. Previously, we localized PSORS2 (psoriasis …

Interferons (IFNs) are cytokines with powerful immunomodulatory and antiviral properties,
but less is known about how they induce cell death. Here, we show that both type I (α/β) and …