Age-related macular degeneration revisited: From pathology and cellular stress to potential therapies

M Hadziahmetovic, G Malek - Frontiers in cell and developmental …, 2021 - frontiersin.org
Age-related macular degeneration (AMD) is a neurodegenerative disease of the aging
retina, in which patients experience severe vision loss. Therapies available to patients are …

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

JR Soucy, EA Aguzzi, J Cho, MJ Gilhooley… - Molecular …, 2023 - Springer
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis

M Yang, MG Tsui, JKW Tsang, RK Goit, KM Yao… - Cell death & …, 2022 - nature.com
Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal
disorders such as retinal degeneration (RD) and age-related macular degeneration (AMD) …

Light pollution: A review of the scientific literature

J Rodrigo-Comino, S Seeling… - The Anthropocene …, 2023 - journals.sagepub.com
Light pollution is the consequence of elevated lighting emitted by human-made artefacts to
the lower atmosphere. Recently, there have been major advances in the assessment and …

Fatty acid oxidation and photoreceptor metabolic needs

Z Fu, TS Kern, A Hellström, LEH Smith - Journal of lipid research, 2021 - ASBMB
Photoreceptors have high energy demands and a high density of mitochondria that produce
ATP through oxidative phosphorylation (OXPHOS) of fuel substrates. Although glucose is …

Thermo-responsive PLGA-PEG-PLGA hydrogels as novel injectable platforms for neuroprotective combined therapies in the treatment of retinal degenerative …

JJ López-Cano, A Sigen, V Andrés-Guerrero, H Tai… - Pharmaceutics, 2021 - mdpi.com
The present study aims to develop a thermo-responsive-injectable hydrogel (HyG) based on
PLGA-PEG-PLGA (PLGA= poly-(DL-lactic acid co-glycolic acid); PEG= polyethylene glycol) …

Non-visual opsins and novel photo-detectors in the vertebrate inner retina mediate light responses within the blue spectrum region

ME Guido, NA Marchese, MN Rios, LP Morera… - Cellular and Molecular …, 2020 - Springer
In recent decades, a number of novel non-visual opsin photopigments belonging to the
family of G protein-coupled receptors, likely involved in a number of non-image-forming …

Diabetic retinopathy and the role of Omega-3 PUFAs: a narrative review

M Georgiou, E Prokopiou - Experimental Eye Research, 2023 - Elsevier
Diabetes mellitus has been a major cause of concern for the past few decades. As the
number of diabetic patients increases, so too does the occurrence of its complications …

[HTML][HTML] The blue light hazard and its use on the evaluation of photochemical risk for domestic lighting. An in vivo study

A Françon, F Behar-Cohen, A Torriglia - Environment International, 2024 - Elsevier
Background Nowadays artificial light highly increases human exposure to light leading to
circadian rhythm and sleep perturbations. Moreover, excessive exposure of ocular structures …

Gpr75 knockout mice display age‐dependent cone photoreceptor cell loss

S Vasudevan, IS Samuels… - Journal of …, 2023 - Wiley Online Library
GPR75 is an orphan G protein‐coupled receptor for which there is currently limited
information and its function in physiology and disease is only recently beginning to emerge …