The number of individuals with the sickle cell trait exceeds 300 million worldwide, making
sickle cell disease one of the most common monogenetic diseases globally. Because of the …

Although largely benign, sickle cell trait (SCT) has been associated with exertion-related
events, to include sudden death. In 2011, a summit on SCT introduced the term exercise …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Mycoplasma pneumoniae is a common pathogen causing respiratory infections in children
and adults. In addition to respiratory diseases, Mycoplasma pneumoniae is also involved in …

Background Splenic infarction is a frequently missed diagnosis in acute clinical conditions
and is often under-diagnosed due to the lack of high-quality evidence on pathophysiology of …

Uday, Yanamandra, Revanth Boddu, Suman Pramanik, Kundan Mishra, Rajan Kapoor,
Ankur Ahuja, Tathagata Chatterjee, and Satyaranjan Das. Prevalence and clinical …

DeLoughery, Thomas G. Anemia at altitude—thalassemia, sickle cell disease, and other
inherited anemias. High Alt Med Biol. 22: 113–118, 2021.—Anemia due to any etiology is a …

Hemoglobin SE (HbSE) disease is a hemoglobinopathy resulting from the combination of
hemoglobin S (HbS) and hemoglobin E (HbE) genotypes. It may present as a vaso …

The sickle cell trait is considered a benign entity that generally does not show clinical
manifestations. However, some complications have been described under certain …

Adult patients with sickle cell disease usually have atrophied spleens due to
autosplenectomy, and only rarely have complications related to the spleen, such as splenic …