A number of hormones and growth factors have been shown to stimulate target cells via
second messenger pathways that in turn regulate the phosphorylation of specific nuclear …

The HTLV Tax protein is crucial for viral replication and for initiating malignant
transformation leading to the development of adult T-cell leukemia. Tax has been shown to …

The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax has
been demonstrated to have transforming activity in multiple cell culture and transgenic …

Adult T-cell leukemia (ATL) is an aggressive hematologic malignancy caused by human T-
cell leukemia virus type I (HTLV-1). Tax, encoded by the HTLV-1 pX region, has been …

The human T-cell leukemia virus type 1 (HTLV-1)-encoded Tax protein activates viral
transcription through interaction with the cellular transcription factor CREB (cyclic AMP …

Human T-cell lymphotropic virus type 1 (HTLV-1) transcriptional activation is mediated by
the viral transactivator, Tax, and three 21-bp repeats (Tax response element [TxRE]) located …

Retroviruses are associated with a variety of diseases, including immunological and
neurological disorders, and various forms of cancer. In humans, the Human T‐cell …

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered.
Studies on HTLV-1 have been instrumental for our understanding of the molecular …

Human T-cell leukemia virus type 1 (HTLV-1) is the only identified oncogenic human
retrovirus. HTLV-1 infects approximately 5–10 million people worldwide and is the infectious …

Human T-cell lymphotropic virus type-1 (HTLV-1) has a large global burden and in some key
communities, such as Indigenous Australians living in remote areas, greater than 45% of …