Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs
Eutectic mixtures have been known for a long time in the pharmaceutical field. However, its
potential as a system to improve the solubility and dissolution of poorly water-soluble drugs …
potential as a system to improve the solubility and dissolution of poorly water-soluble drugs …
Emerging multi-drug eutectics: opportunities and challenges
Complexity and heterogeneous nature of most diseases have posed greater challenges in
the modern healthcare system. Fixed-dose combination can offer an ideal way to improve …
the modern healthcare system. Fixed-dose combination can offer an ideal way to improve …
Therapeutic deep eutectic system of capric acid and menthol: Characterization and pharmaceutical application
The work outlined herein describes an evaluation of a new green solvent working as a drug
solubility enhancer made up of a eutectic system comprising mixtures of capric acid and …
solubility enhancer made up of a eutectic system comprising mixtures of capric acid and …
Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient‐Free Dry Powder for Inhalation
Curcumin has shown beneficial effects on pulmonary diseases with chronic inflammation or
abnormal inflammatory responses, including chronic obstructive pulmonary disease …
abnormal inflammatory responses, including chronic obstructive pulmonary disease …
Eutexia for enhanced dissolution rate and anti-inflammatory activity of nonsteroidal anti-inflammatory agents: Caffeine as a melting point modulator
Fast dissolution of nonsteroidal anti-inflammatory drugs (NSAIDs) is a prerequisite from
patient perspective. However, most NSAIDs are slowly dissolving acidic compounds …
patient perspective. However, most NSAIDs are slowly dissolving acidic compounds …
Increasing the bromazepam solubility by forming eutectic mixture with citric acid
Bromazepam, citric acid and their binary mixtures were analysed by Differential Scanning
Calorimetry. For the bromazepam molar fraction 0.7, the mixture presents a eutectic which …
Calorimetry. For the bromazepam molar fraction 0.7, the mixture presents a eutectic which …
Preformulation studies of ezetimibe-simvastatin solid dispersions in the development of fixed-dose combinations
A Górniak, A Złocińska, M Trojan, A Pęcak… - Pharmaceutics, 2022 - mdpi.com
Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and
ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for …
ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for …
Synthesis of Celecoxib-Eutectic Mixture Particles via Supercritical CO2 Process and Celecoxib Immediate Release Tablet Formulation by Quality by Design Approach
Significant improvements in the wettability and dissolution rate of celecoxib (CEL), a poorly
soluble selective cyclooxygenase-2 (COX-2) inhibitor, have been shown by Huyn et al …
soluble selective cyclooxygenase-2 (COX-2) inhibitor, have been shown by Huyn et al …
Rivaroxaban eutectics with improved solubility, dissolution rates, bioavailability and stability
Rivaroxaban (RXB) is a direct factor Xa inhibitor used for the treatment of deep vein
thrombosis (DVT, a blood clot in the leg) and pulmonary embolism (PE, a blood clot in the …
thrombosis (DVT, a blood clot in the leg) and pulmonary embolism (PE, a blood clot in the …
Bergenin-isonicotinamide (1: 1) cocrystal with enhanced solubility and investigation of its solubility behavior
H Liu, H Lin, Z Zhou, L Li - Journal of Drug Delivery Science and …, 2021 - Elsevier
Bergenin (BER) is a bioactive compound used for the treatment of chronic bronchitis in
China. However, its low solubility and permeation limits its oral bioavailability. In this study, a …
China. However, its low solubility and permeation limits its oral bioavailability. In this study, a …