The cyclin D1 proto-oncogene exercises powerful control over the mechanisms that regulate
the mitotic cell cycle, and excessive cyclin D1 expression and/or activity is common in …

Loss of RB1 gene is considered either a causal or an accelerating event in retinoblastoma.
A variety of mechanisms inactivates RB1 gene, including intragenic mutations, loss of …

G0 is a physiological state occupied by resting or terminally differentiated cells that have
exited the cell cycle. In contrast to the well-characterized cyclin/cdk-mediated inactivation of …

p107 and p130 were originally identified as targets of the transforming domains of viral
oncoproteins encoded by small DNA tumor viruses. Together with pRB, the protein product …

The DREAM complex represses cell cycle genes during quiescence through scaffolding
MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130. Upon cell …

The retinoblastoma/pocket protein family is one of the master regulators of the eukaryotic
cell cycle. It includes the retinoblastoma protein (Rb) and the related p107 and p130 …

The retinoblastoma protein (RB) restricts cell cycle gene expression and entry into the cell
cycle. The RB-related protein p130 forms the DREAM (DP, RB-like, E2F, and MuvB) …

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-
dependent kinase (CDK)–cyclin protein complex. However, control of the G0-to-G1 transition …

The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of
pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in …

Tri-methylation of Histone 3 lysine 4 (H3K4) is an important epigenetic modification whose
deposition and removal can affect the chromatin at structural and functional levels. KDM5A …