Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …

NADPH oxidases (NOXs) are transmembrane enzymes that are devoted to the production of
reactive oxygen species (ROS). In cancers, dysregulation of NOX enzymes affects ROS …

Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …

Cancer is the leading cause of death worldwide after cardiovascular diseases. This has
been the case for the last few decades despite there being an increase in the number of …

NADPH-oxidases (NOXs) purposefully produce reactive-oxygen-species (ROS) and are
found in most kingdoms of life. The seven human NOXs are each characterized by a specific …

Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …

Highlights•Collective migration relies on the ability of a multicellular co-ordinated unit to
efficiently respond to physical changes in their surrounding matrix.•Conversely, migrating …