[HTML][HTML] Advances in the antimicrobial treatment of osteomyelitis

C Zhong, Y Wu, H Lin, R Liu - Composites Part B: Engineering, 2023 - Elsevier
Osteomyelitis is a major complication of orthopedic diseases with high recurrence and
morbidity, along with long hospital stays and high medical costs. The conventional treatment …

Local antibiotics in the treatment of diabetic foot infections: a narrative review

L Soldevila-Boixader, AP Fernandez, JM Laguna… - Antibiotics, 2023 - mdpi.com
Along with the increasing global burden of diabetes, diabetic foot infections (DFI) and
diabetic foot osteomyelitis (DFO) remain major challenges for patients and society. Despite …

Application and clinical effectiveness of antibiotic‐loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers …

RE Mendame Ehya, H Zhang, B Qi… - Journal of Diabetes …, 2021 - Wiley Online Library
This study explored the clinical effectiveness of antibiotic‐loaded bone cement on primary
treatment of diabetic foot infection. This is a randomized controlled study, including thirty‐six …

Infected bone resection plus adjuvant antibiotic-impregnated calcium sulfate versus infected bone resection alone in the treatment of diabetic forefoot osteomyelitis

CH Qin, CH Zhou, HJ Song, GY Cheng… - BMC musculoskeletal …, 2019 - Springer
Background Managing with diabetic foot osteomyelitis (DFO) is challenging. Even after
infective bone resection and thorough debridement, DFO is still difficult to cure and has a …

Investigation and management of diabetic foot osteomyelitis: An update for the foot and ankle orthopaedic surgeon

Y Alkhalfan, TL Lewis, V Kavarthapu… - Journal of Clinical …, 2024 - Elsevier
Diabetic foot osteomyelitis (DFO) poses a significant challenge in the management of
diabetic patients, often leading to severe complications and increased morbidity. Effective …

Multidisciplinary approach for the management and treatment of diabetic foot infections with a resorbable, gentamicin-loaded bone graft substitute

C Whisstock, A Volpe, S Ninkovic, M Marin… - Journal of Clinical …, 2020 - mdpi.com
Diabetic patients are at increased risk of developing foot ulcers which may cause bone
infections associated with a high probability of both amputation and mortality. Therefore …

Meta-analysis: outcomes of surgical and medical management of diabetic foot osteomyelitis

DH Truong, R Bedimo, M Malone… - Open Forum …, 2022 - academic.oup.com
Background The aim of this study was to evaluate clinical outcomes in the published
literature on medical and surgical management of diabetic foot osteomyelitis (DFO) …

Outcome Analysis of the Use of Cerament® in Patients with Chronic Osteomyelitis and Corticomedullary Defects

M Niemann, F Graef, SS Ahmad, KF Braun, U Stöckle… - Diagnostics, 2022 - mdpi.com
Background: Chronic osteomyelitis (OM) is a progressive but mostly low-grade infection of
the bones. The management of this disease is highly challenging for physicians. Despite …

Surgical treatment of diabetic foot ulcers complicated by osteomyelitis with gentamicin-loaded calcium sulphate-hydroxyapatite biocomposite

KH Hutting, WB aan de Stegge, JJ van Netten… - Journal of clinical …, 2021 - mdpi.com
Diabetic foot ulcers, complicated by osteomyelitis, can be treated by surgical resection, dead
space filling with gentamicin-loaded calcium sulphate-hydroxyapatite (CaS-HA) …

Management of bone diseases: Looking at scaffold-based strategies for drug delivery

M Bordone, A Bettencourt - Drug Delivery and Translational Research, 2023 - Springer
The bone tissue can regenerate itself completely and continuously; however, large-scale
bone defects may overpower this self-regenerative process. Furthermore, the aging …