T Follicular Helper Cell Heterogeneity
T follicular helper (Tfh) cells specialize in helping B cells and are therefore critical
contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class …
contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class …
Immune cells in skin inflammation, wound healing, and skin cancer
Y Zhang, Q Lu - Journal of Leukocyte Biology, 2024 - academic.oup.com
Given the self-evident importance of cutaneous immunity in the maintenance of body-
surface homeostasis, disturbance of the steady-state skin is inextricably intertwined with …
surface homeostasis, disturbance of the steady-state skin is inextricably intertwined with …
T-cell help in the germinal center: homing in on the role of IL-21
L Petersone, LSK Walker - International Immunology, 2024 - academic.oup.com
Abstract Interleukin 21 (IL-21) is a pleiotropic cytokine that is overproduced in multiple
autoimmune settings. Provision of IL-21 from follicular helper T cells is an important …
autoimmune settings. Provision of IL-21 from follicular helper T cells is an important …
[HTML][HTML] Cytokines in follicular helper T cell biology in physiologic and pathologic conditions
Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs)
and establishing immunological memory. Cytokines, among other functional molecules …
and establishing immunological memory. Cytokines, among other functional molecules …
Transcriptional regulation of Tfh dynamics and the formation of immunological synapses
Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with
immune cells and strategic localization between the dark and light zones to clonally expand …
immune cells and strategic localization between the dark and light zones to clonally expand …
[HTML][HTML] Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function
SA Wellford, PL Schwartzberg - Current Opinion in Immunology, 2024 - Elsevier
Highlights•Tfh cells are phenotypically diverse.•Complex signaling and metabolic networks
control Tfh cell differentiation.•The context in which Tfh are generated affects their …
control Tfh cell differentiation.•The context in which Tfh are generated affects their …
SAP-expressing T peripheral helper cells identify systemic lupus erythematosus patients with lupus nephritis
Y Gartshteyn, L Geraldino-Pardilla, L Khalili… - Frontiers in …, 2024 - frontiersin.org
Introduction T follicular (TFH) and peripheral helper (TPH) cells have been increasingly
recognized as a pathogenic subset of CD4 T cells in systemic lupus erythematosus (SLE) …
recognized as a pathogenic subset of CD4 T cells in systemic lupus erythematosus (SLE) …
Enhancing immune protection against MERS-CoV: the synergistic effect of proteolytic cleavage sites and the fusion peptide and RBD domain targeting VLP …
Introduction The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic
infectious virus that has caused significant outbreaks in the Middle East and beyond. Due to …
infectious virus that has caused significant outbreaks in the Middle East and beyond. Due to …
Association between MEF2 family gene polymorphisms and susceptibility to multiple sclerosis in Chinese population
L Wu, B Liu, Y Wei, P Lu - Acta Neurologica Belgica, 2024 - Springer
Purpose Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory
demyelinating lesions in the white matter of the central nervous system. Myocyte enhancer …
demyelinating lesions in the white matter of the central nervous system. Myocyte enhancer …
The Role of Myocyte Enhancer Factor 2D in Beta-Cells: Implications for Glucose Homeostasis and Cell Survival
JE Crabtree - 2023 - scholarsarchive.byu.edu
Abstract Myocyte Enhancer Factor 2D (Mef2D) is a member of the Mef2 family. As a
transcription factor, Mef2D regulates the expression of genes that impinge on cellular …
transcription factor, Mef2D regulates the expression of genes that impinge on cellular …