The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …

A unique feature of systemic sclerosis (SSc) that distinguishes it from other fibrotic disorders
is that autoimmunity and vasculopathy characteristically precede fibrosis. Moreover, fibrosis …

Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …

Abnormal and exaggerated deposition of extracellular matrix is the hallmark of many fibrotic
diseases, including systemic sclerosis and pulmonary, liver, and kidney fibrosis. The …

Systemic sclerosis (SSc) is a complex and incompletely understood disease associated with
fibrosis in multiple organs. Recent findings identify transforming growth factor-ß (TGF-ß), Wnt …

The transforming growth factor (TGF)-β/Smad3 signaling pathway is considered a central
mediator of pathological organ fibrosis; however, contribution of Smad2/3-independent TGF …

Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment
options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera; Biogen …

Generalized vitiligo is an acquired disorder in which patches of depigmented skin, overlying
hair and oral mucosa result from progressive autoimmune loss of melanocytes from the …

Systemic sclerosis (SSc) is a rare connective tissue disease characterized by vascular
remodeling, fibroblast activation and extra-cellular matrix production in excess and …

Pulmonary arterial hypertension (PAH) is a fatal condition for which there is no cure.
Dimethyl Fumarate (DMF) is an FDA approved anti-oxidative and anti-inflammatory agent …