Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

Alzheimer's disease (AD) is the most common cause of senile dementia. Although AD
research has made important breakthroughs, the pathogenesis of this disease remains …

Increased dietary intake of niacin has been correlated with reduced risk of Alzheimer's
disease (AD). Niacin serves as a high-affinity ligand for the receptor HCAR2 (GPR109A). In …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by complex
pathophysiological features. Amyloid plaques resulting from extracellular amyloid deposition …

Background: Circular RNAs (circRNAs), as covalently closed single-stranded noncoding
RNA molecules, have been recently identified to involve in several biological processes …

Background Despite its identification as a key checkpoint regulator of microglial activation in
Alzheimer's disease, the overarching role of CX3CR1 signaling in modulating mechanisms …

The role of microglia in controlling synapse homeostasis is becoming increasingly
recognized by the scientific community. In particular, the microglia-mediated elimination of …

As tissue-resident macrophages of the brain, microglia are increasingly considered as
cellular targets for therapeutical intervention. Innate immune responses in particular have …

In microglia, changes in intracellular calcium concentration ([Ca2+] i) may regulate process
motility, inflammasome activation, and phagocytosis. However, while neurons and …

In microglia, changes in intracellular calcium concentration ([Ca2+] i) may regulate process
motility, inflammasome activation, and phagocytosis. However, while neurons and …