ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

Alzheimer's disease (AD) is the most common form of dementia but has no effective
treatment. A comprehensive investigation of cell type-specific responses and cellular …

Synapse loss and Tau pathology are hallmarks of Alzheimer's disease (AD) and other
tauopathies, but how Tau pathology causes synapse loss is unclear. We used unbiased …

Alzheimer's disease (AD) is a progressive and synaptic failure disease. Despite the many
years of research, AD still harbors many secrets. As more of the world's population grows …

A major obstacle in Alzheimer's disease (AD) research is the lack of predictive and
translatable animal models that reflect disease progression and drug efficacy. Transgenic …

The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …

Dynamic gain and loss of synapses is fundamental to healthy brain function. While
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …