Despite recent advances in our understanding of the disease, glioblastoma (GB) continues
to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify …

E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression. F-
box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase …

The expression of the transcriptional repressor Hes1 oscillates in many cell types, including
neural progenitor cells (NPCs), but the significance of Hes1 oscillations in development is …

Simple Summary Diffuse midline gliomas (DMGs) remain one of the most devastating
childhood brain tumour types, for which there is currently no known cure. In this review we …

The recent advances in high throughput sequencing technology have drastically changed
the practice of medical diagnosis, allowing for rapid identification of hundreds of genes …

The developmentally indispensable Notch pathway exhibits a high grade of pleiotropism in
its biological output. Emerging evidence supports the notion of post-translational …

Self-renewal genes maintain stem cells in an undifferentiated state by preventing the
commitment to differentiate. Robust inactivation of self-renewal gene activity following …

Indirect neurogenesis, during which neural stem cells generate neurons through
intermediate progenitors, drives the evolution of lissencephalic brains to gyrencephalic …

Cerebral infarction is with poorer prognosis and high rates of mortality. After cerebral
infarction, the promoting angiogenesis can accelerate the recovery of neurological function …

Molecular dynamics (MD) simulation has become a powerful tool for studying the structures
and functional mechanisms of biomolecules, and its reliability crucially depends on the …