IgG subclasses and allotypes: from structure to effector functions
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
Isotype and glycoform selection for antibody therapeutics
R Jefferis - Archives of biochemistry and biophysics, 2012 - Elsevier
We live in a hostile environment but are protected by the innate and adaptive immune
system. A major component of the latter is mediated by antibody molecules that bind to …
system. A major component of the latter is mediated by antibody molecules that bind to …
Precision glycocalyx editing as a strategy for cancer immunotherapy
H Xiao, EC Woods, P Vukojicic… - Proceedings of the …, 2016 - National Acad Sciences
Cell surface sialosides constitute a central axis of immune modulation that is exploited by
tumors to evade both innate and adaptive immune destruction. Therapeutic strategies that …
tumors to evade both innate and adaptive immune destruction. Therapeutic strategies that …
A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface
S Bangaru, S Lang, M Schotsaert, HA Vanderven… - Cell, 2019 - cell.com
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Y Latchman, CR Wood, T Chernova, D Chaudhary… - Nature …, 2001 - nature.com
Abstract Programmed death 1 (PD-1)–deficient mice develop a variety of autoimmune-like
diseases, which suggests that this immunoinhibitory receptor plays an important role in …
diseases, which suggests that this immunoinhibitory receptor plays an important role in …
Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc
EE Idusogie, LG Presta… - The Journal of …, 2000 - journals.aai.org
Rituxan (Rituximab) is a chimeric mAb with human IgG1 constant domains used in the
therapy of non-Hodgkin's B cell lymphomas. This Ab targets B cells by binding to the cell …
therapy of non-Hodgkin's B cell lymphomas. This Ab targets B cells by binding to the cell …
Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1
M Hezareh, AJ Hessell, RC Jensen… - Journal of …, 2001 - Am Soc Microbiol
The human antibody immunoglobulin G1 (IgG1) b12 neutralizes a broad range of human
immunodeficiency virus-type 1 (HIV-1) isolates in vitro and is able to protect against viral …
immunodeficiency virus-type 1 (HIV-1) isolates in vitro and is able to protect against viral …
Refined Structure of an Intact IgG2a Monoclonal Antibody,
LJ Harris, SB Larson, KW Hasel, A McPherson - Biochemistry, 1997 - ACS Publications
The structure of an intact, anti-canine lymphoma monoclonal antibody (Mab231) 1 was
determined by molecular replacement and refined in a triclinic cell to an R-value of 20.9 …
determined by molecular replacement and refined in a triclinic cell to an R-value of 20.9 …
Optimized Fc variants
GA Lazar, AJ Chirino, W Dang, JR Desjarlais… - US Patent …, 2008 - Google Patents
2004-11-10 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …
Recombinant human IgG molecules lacking Fcγ receptor I binding and monocyte triggering activities
Subclasses of human IgG have a range of activity levels with different effector systems but
each triggers at least one mechanism of cell destruction. We are aiming to engineer non …
each triggers at least one mechanism of cell destruction. We are aiming to engineer non …