Directed evolution: methodologies and applications

Y Wang, P Xue, M Cao, T Yu, ST Lane… - Chemical reviews, 2021 - ACS Publications
Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

Vascular endothelial cells: heterogeneity and targeting approaches

JK Hennigs, C Matuszcak, M Trepel, J Körbelin - Cells, 2021 - mdpi.com
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Advancement and applications of peptide phage display technology in biomedical science

CH Wu, IJ Liu, RM Lu, HC Wu - Journal of biomedical science, 2016 - Springer
Combinatorial phage library is a powerful research tool for high-throughput screening of
protein interactions. Of all available molecular display techniques, phage display has proven …

Phage display screening of therapeutic peptide for cancer targeting and therapy

PE Saw, EW Song - Protein & cell, 2019 - academic.oup.com
Recently, phage display technology has been announced as the recipient of Nobel Prize in
Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be …

Nanocrystal targeting in vivo

ME Åkerman, WCW Chan… - Proceedings of the …, 2002 - National Acad Sciences
Inorganic nanostructures that interface with biological systems have recently attracted
widespread interest in biology and medicine. Nanoparticles are thought to have potential as …

[HTML][HTML] Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

KN Lam, P Spanogiannopoulos, P Soto-Perez… - Cell Reports, 2021 - cell.com
Mechanistic insights into the role of the human microbiome in the predisposition to and
treatment of disease are limited by the lack of methods to precisely add or remove microbial …

[图书][B] Bacteriophages: biology and applications

E Kutter, A Sulakvelidze - 2004 - taylorfrancis.com
In response to the emergence of pathogenic bacteria that cannot be treated with current
antibiotics, many researchers are revisiting the use of bacteriophages, or phages, to fight …

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis

R Pasqualini, E Koivunen, R Kain, J Lahdenranta… - Cancer research, 2000 - AACR
Phage that display a surface peptide with the NGR sequence motif home selectively to tumor
vasculature in vivo. A drug coupled to an NGR peptide has more potent antitumor effects …

Bacteriophages and their implications on future biotechnology: a review

IU Haq, WN Chaudhry, MN Akhtar, S Andleeb, I Qadri - Virology journal, 2012 - Springer
Recently it has been recognized that bacteriophages, the natural predators of bacteria can
be used efficiently in modern biotechnology. They have been proposed as alternatives to …