Biologically active indolizidine alkaloids

J Zhang, SL Morris‐Natschke, D Ma… - Medicinal Research …, 2021 - Wiley Online Library
Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial
plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of …

Synthetic Strategies for the Construction of Indolizines and Indolizine‐fused Compounds: Thienoindolizines and Indolizinoindoles

AA Nevskaya, AD Zinoveva… - Asian Journal of …, 2023 - Wiley Online Library
This paper provides a review on various methodologies developed for the synthesis of
different indolizine derivatives and an overview of their application. These include …

Skeletal remodeling of chalcone-based pyridinium salts to access isoindoline polycycles and their bridged derivatives

L Wang, H Han, L Gu, W Zhang, J Zhao, Q Wang - Chemical Science, 2021 - pubs.rsc.org
Simultaneous deconstructive ring-opening and skeletal reconstruction of an inert, aromatic
pyridinium ring is of great importance in synthetic communities. However, research in this …

C–H/C–C functionalization approach to N-fused heterocycles from saturated azacycles

JS Ham, B Park, M Son, JB Roque… - Journal of the …, 2020 - ACS Publications
Herein we report the synthesis of substituted indolizidines and related N-fused bicycles from
simple saturated cyclic amines through sequential C–H and C–C bond functionalizations …

Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade

T Wagener, M Pierau, A Heusler… - Advanced Synthesis & …, 2022 - Wiley Online Library
Saturated N‐heterocycles are prominent motifs found in various natural products and
pharmaceuticals. Despite the increasing interest in this class of compounds, the synthesis of …

Synthesis of fungicidal morpholines and isochromenopyridinones via acid-catalyzed intramolecular reactions of isoindolinones

X Liu, Y Sun, S Hong, X Ji, W Gao, H Yuan… - Organic & …, 2024 - pubs.rsc.org
Acid-catalyzed intramolecular cyclization or rearrangement of isoindolinone derivatives is
described. 3-Hydroxy/ethoxy-3, 4-dihydro-6H-[1, 4]-oxazino-[3, 4-a]-isoindol-6-ones are …

An aza-Robinson Annulation Strategy for the Synthesis of Fused Bicyclic Amides: Synthesis of (±)-Coniceine and Quinolizidine

A Garay-Talero, TAC Goulart, RDC Gallo… - Organic …, 2023 - ACS Publications
An aza-Robinson annulation strategy is described using a NaOEt-catalyzed conjugate
addition of cyclic imides onto vinyl ketones, followed by a TfOH-mediated intramolecular …

Cyclization Strategies Using Imide Derivatives for the Synthesis of Polycyclic Nitrogen‐Containing Compounds

Y Quevedo‐Acosta, ID Jurberg… - European Journal of …, 2022 - Wiley Online Library
Cyclization strategies employing imides and their derivatives have attracted the attention of
several organic chemists interested in synthesizing polycyclic alkaloids. Numerous …

Enantioselective Synthesis of Isoindolones via Palladium – Catalyzed Intramolecular Heck‐Mizoroki Reactions of Endocyclic Enamides Using N,N‐Ligands

C Wiethan, IB Braga, VH Menezes da Silva… - …, 2023 - Wiley Online Library
The enantioselective synthesis of isoindolones via Heck‐Mizoroki reactions of endocyclic
enamides using a palladium‐bis (oxazoline) catalyst system is described. The N, N‐ligands …

Nitrogen-bridgehead compounds: overview, synthesis, and outlook on applications

BW Grau, P Kumar, A Nilsen… - Organic & Biomolecular …, 2025 - pubs.rsc.org
The nitrogen-bridgehead is a common structural motif present in a multitude of natural
products. As many of these abundant compounds exhibit biological activities, eg against …