Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

The acidic tumour microenvironment is now recognized as a tumour phenotype that drives
cancer somatic evolution and disease progression, causing cancer cells to become more …

The employment of spectroscopically-resolved NMR techniques as analytical probes have
previously been both prohibitively expensive and logistically challenging in view of the large …

Hyperpolarization stands out as a technique capable of significantly enhancing the
sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) …

Nuclear magnetic resonance (NMR) has become a universal method for biochemical and
biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging …

The development of hyperpolarized bioresponsive probes for magnetic resonance imaging
(MRI) applications is an emerging and rapidly growing topic in chemistry. A wide range of …

The setup, operational procedures and performance of a cryogen-free device for producing
hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a …

Dysregulation of pH in solid tumors is a hallmark of cancer. In recent years, the role of
altered pH heterogeneity in space, between benign and aggressive tissues, between …

In vivo monitoring of cerebral pH is of great significance because its disturbance is related to
some pathological processes such as neurodegenerative diseases, for example …

Azide moieties, unique linear species containing three nitrogen atoms, represent an
attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI) …