Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly (Spermine Acrylamides) for the Treatment of Lung Fibrosis
RNA interference (RNAi) is an efficient strategy to post‐transcriptionally silence gene
expression. While all siRNA drugs on the market target the liver, the lung offers a variety of …
expression. While all siRNA drugs on the market target the liver, the lung offers a variety of …
Molecular Dynamics Simulations Elucidate the Molecular Organization of Poly (beta-amino ester) Based Polyplexes for siRNA Delivery
KM Steinegger, L Allmendinger, S Sturm… - Nano Letters, 2024 - ACS Publications
Cationic polymers are known to efficiently deliver nucleic acids to target cells by
encapsulating the cargo into nanoparticles. However, the molecular organization of these …
encapsulating the cargo into nanoparticles. However, the molecular organization of these …
Design of Experiments Grants Mechanistic Insights into the Synthesis of Spermine-Containing PBAE Copolymers
APE Kromer, F Sieber-Schäfer… - … Applied Materials & …, 2024 - ACS Publications
Successful therapeutic delivery of siRNA with polymeric nanoparticles seems to be a
promising but not vastly understood and complicated goal to achieve. Despite years of …
promising but not vastly understood and complicated goal to achieve. Despite years of …
Co-delivery of dasatinib and miR-30a by liposomes targeting neuropilin-1 receptors for triple-negative breast cancer therapy
Combinational therapy to treat triple-negative breast cancer (TNBC) by concomitantly
influencing different cellular pathways has attracted attention recently. In the present study …
influencing different cellular pathways has attracted attention recently. In the present study …
Role of Hydrophobic Modification in Spermine-Based Poly (β-amino ester) s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage
Y Jin, X Wang, APE Kromer, JT Müller… - …, 2024 - ACS Publications
After RNAi was first discovered over 20 years ago, siRNA-based therapeutics are finally
becoming reality. However, the delivery of siRNA has remained a challenge. In our previous …
becoming reality. However, the delivery of siRNA has remained a challenge. In our previous …
A novel micelleplex for tumour-targeted delivery of CRISPR-Cas9 against KRAS-mutated lung cancer
S Chen, M Triki, SP Carneiro, OM Merkel - Nanoscale, 2025 - pubs.rsc.org
CRISPR-Cas9 has emerged as a highly effective and customizable genome editing tool,
holding significant promise for the treatment of KRAS mutations in lung cancer. In this study …
holding significant promise for the treatment of KRAS mutations in lung cancer. In this study …
[PDF][PDF] Tumor-targeted delivery of Cas9 mRNA and sgRNA against KRAS-mutated lung cancer
S Chen - 2024 - edoc.ub.uni-muenchen.de
1. Abstract According to the Global Cancer Statistics 2022, lung cancer is the most
commonly diagnosed cancer and the leading cause of cancer-related deaths worldwide. 1 …
commonly diagnosed cancer and the leading cause of cancer-related deaths worldwide. 1 …