[HTML][HTML] Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners

M Šrejber, V Navrátilová, M Paloncýová… - Journal of inorganic …, 2018 - Elsevier
Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …

Chemiosmotic and murburn explanations for aerobic respiration: predictive capabilities, structure-function correlations and chemico-physical logic

KM Manoj, V Soman, VD Jacob, A Parashar… - Archives of biochemistry …, 2019 - Elsevier
Since mid-1970s, the proton-centric proposal of 'chemiosmosis' became the acclaimed
explanation for aerobic respiration. Recently, significant theoretical and experimental …

[HTML][HTML] Functional expression and regulation of eukaryotic cytochrome P450 enzymes in surrogate microbial cell factories

P Durairaj, S Li - Engineering Microbiology, 2022 - Elsevier
Cytochrome P450 (CYP) enzymes play crucial roles during the evolution and diversification
of ancestral monocellular eukaryotes into multicellular eukaryotic organisms due to their …

Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation

KM Manoj, S Ramasamy, A Parashar… - Biomolecular …, 2020 - degruyter.com
The inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological
regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition …

[HTML][HTML] Light's interaction with pigments in chloroplasts: The murburn perspective

KM Manoj, A Manekkathodi - Journal of Photochemistry and Photobiology, 2021 - Elsevier
The prevailing understanding on the light reaction of oxygenic photosynthesis (photolytic
photophosphorylation & NADPH synthesis) considers the vast majority of the diverse …

[HTML][HTML] Structural foundations for explaining the physiological roles of murzymes embedded in diverse phospholipid membranes

KM Manoj, DA Gideon - Biochimica et Biophysica Acta (BBA) …, 2022 - Elsevier
The advent of improved structural biology protocols and bioinformatics methodologies have
provided paradigm-shifting insights on metabolic or physiological processes catalyzed by …

Aerobic respiration: proof of concept for the oxygen-centric murburn perspective

KM Manoj, A Parashar, V David Jacob… - Journal of …, 2019 - Taylor & Francis
The inner mitochondrial membrane protein complexes (I–V) and prokaryotic respiratory
machinery are examined for a deeper understanding of their structure–function correlations …

Validating the predictions of murburn model for oxygenic photosynthesis: Analyses of ligand-binding to protein complexes and cross-system comparisons

KM Manoj, DA Gideon, A Parashar… - Journal of …, 2022 - Taylor & Francis
In this second half of our treatise on oxygenic photosynthesis, we provide support for the
murburn model of the light reaction of photosynthesis and ratify key predictions made in the …

Regulation of human cytochrome P4501A1 (hCYP1A1): a plausible target for chemoprevention?

R Santes-Palacios, D Ornelas-Ayala… - BioMed research …, 2016 - Wiley Online Library
Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in
precarcinogen metabolism; for this reason it is relevant to know more in depth the …

Why do cells need oxygen? Insights from mitochondrial composition and function

KM Manoj, DA Gideon, L Jaeken - Cell Biology International, 2022 - Wiley Online Library
Mitochondrial membrane‐embedded redox proteins are classically perceived as
deterministic “electron transport chain”(ETC) arrays cum proton pumps; and oxygen is seen …