Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization.
The over-expression of cofilin is observed in various cancers, cofilin promotes cancer …

Simple Summary There are three subfamilies of human PDZ-LIM family proteins with a total
of 10 protein molecules, and PDZ-LIM family proteins serve as a class of scaffolding proteins …

Deaths caused by coronavirus disease 2019 (COVID-19) are largely due to the lungs
edema resulting from the disruption of the lung alveolo-capillary barrier, induced by SARS …

Programmed death ligand 1 (PD-L1) immune checkpoint inhibitors are promising
therapeutic agents for treating cancers but the response rate is< 20%. Some …

Background Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that
is used as an immunopotentiator for anti-tumor therapies in recent years. We found that …

Targeting cytokinesis can suppress tumor growth by blocking cell division and promoting
apoptosis. We aimed to characterize key cytokinesis regulator in hepatocellular carcinoma …

ERK pathway regulated the programmed death ligand-1 (PD-L1) expression which was
linked to the response of programmed death-1 (PD-1)/PD-L1 blockade therapy. So it is …

Multidrug resistance (MDR) is the major cause of chemotherapy failure, which is usually
caused by the overexpression of ATP-binding cassette (ABC) transporters such as ABCB1 …

The Mediator complex is an essential coregulator of RNA polymerase II transcription. More
recent developments suggest Mediator functions as a link between transcription regulation …

Transcriptional dysregulation is central to many diseases including cancer. Mutation or
deregulated expression of proteins involved in transcriptional machinery leads to aberrant …