Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

Cytosolic DNA arising from intracellular pathogens triggers a powerful innate immune
response,. It is sensed by cyclic GMP–AMP synthase (cGAS), which elicits the production of …

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells.
Owing to their ability to produce ATP through respiration, they became a driving force in …

Dynamic ensembles of macromolecules mediate essential processes in biology.
Understanding the mechanisms driving the function and molecular interactions …

Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A
(TFAM) into mitochondrial nucleoids that are of key importance in controlling the …

The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mt DNA)‐binding
protein essential for genome maintenance. TFAM functions in determining the abundance of …

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome and a dedicated DNA replication machinery is required for its maintenance. Many …

Mitochondrial transcription factor A (mtTFA, mtTF1, TFAM) is an essential protein that binds
mitochondrial DNA (mtDNA) with and without sequence specificity to regulate both …

Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy
demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA …