The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Disrupted interoception is a prominent feature of the diagnostic classification of several
psychiatric disorders. However, progress in understanding the interoceptive basis of these …

Cholecystokinin (CCK) has emerged as an important mammalian neuropeptide, localized in
peripheral organs and in the central nervous system. This review presents an overview of …

The peptide cholecystokinin (CCK) 2 was originally discovered in the gastrointestinal tract
(Ivy and Oldberg, 1928) and has been shown to mediate pancreatic secretion and …

Background Positron emission tomography (PET) allows the measurement of
benzodiazepine–γ-aminobutyric acid A (GABA A) receptor kinetics. We employed flumazenil …

Much data has accumulated over the past decade supporting the hypothesis that CCK plays
a role in the neurobiology of anxiety and panic attacks. These data originated from animal …

Background: We investigated whether the selective brain cholecystokinin (CCK B) receptor
antagonist, L-365, 260, could antagonize the panicogenic effects of CCKtetrapeptide (CCK …

Honokiol, a neolignane derivative of Magnolia bark, has central depressant action and, at
much lower doses, anxiolytic activity. We have investigated the characteristics of the …

Of all the therapeutic areas, diseases of the CNS provide the biggest challenges to
translational research in this era of increased productivity and novel targets. Risk reduction …

Cholecystokinin (CCK) plays an important role in both the alimentary tract and the central
nervous system (CNS). At present it seems to be the most abundant neuropeptide in the …