Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

Small molecules with molecular weights less than 1500 Da represented by natural
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …

Imaging mass spectrometry (IMS) technologies are capable of mapping a wide array of
biomolecules in diverse cellular and tissue environments. IMS has emerged as an essential …

Single cell analysis strives to probe molecular heterogeneity in morphologically similar cell
populations through quantitative or qualitative measurements of genetic, proteomic, or …

In recent years, ion mobility spectrometry-mass spectrometry (IMS-MS) has advanced the
field of omics-based research, especially with the development of high-resolution platforms; …

Lipids are a major class of molecules that play key roles in different biological processes.
Understanding their biological roles and mechanisms remains analytically challenging due …

Abstract Ion Mobility Spectrometry (IMS) is a widely used technique for the post-ionization
separation and structural characterization of biomolecules. Trapped IMS (TIMS) is a …

A fast and fully automated method for chiral analysis has been developed by combining a
chiral derivatization approach with high-resolution trapped ion mobility separation. Although …

Glycosaminoglycans (GAGs) play vital roles in many biological processes and are naturally
present as complex mixtures of polysaccharides with tremendous structural heterogeneity …

Ion mobility spectrometry-mass spectrometry (IMS-MS) determines momentum transfer cross
sections of ions to elucidate their structures. Recent IMS methods employ electrodynamic …