In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …

Unlike the complex glycans decorating the cell surface, the O-linked β-N-acetyl glucosamine
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia,
with absolute insulin deficiency or insulin resistance as the main cause, and causes damage …

Mitochondria are important for providing cellular energy ATP through the oxidative
phosphorylation pathway. They are also critical in regulating many cellular functions …

O-Linked N-acetylglucosamine transferase (OGT) catalyzes O-GlcNAcylation of target
proteins and regulates numerous biological processes. OGT is encoded by a single gene …

The use of the carbohydrate glucose as an energetic source is essential for an adequate
function of the human body. The complex regulation of this molecule involves the …

Parkinson's disease (PD) is a movement disorder with widespread neurodegeneration in the
brain. Significant oxidative, reductive, metabolic, and proteotoxic alterations have been …

Background: Alzheimer's disease is a neurodegenerative disease characterized by gradual
declines in social, cognitive, and emotional functions, leading to a loss of expected social …

Alzheimer's disease (AD) and diabetes mellitus, especially type 2 (T2DM), are very common
and widespread diseases in contemporary societies, and their incidence is steadily on the …

O-linked N-acetylglucosamine modification (O-GlcNAcylation) is a nutrient-dependent
protein post-translational modification (PTM), dynamically and reversibly driven by two …