Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Orthostatic hypotension is an unusually large decrease in blood pressure on standing that
increases the risk of adverse outcomes even when asymptomatic. Improvements in …

Although dopamine replacement therapy remains a core component of Parkinson's disease
treatment, the onset of motor fluctuations and dyskinetic movements might require a range of …

Despite significant efficacy, one of the major limitations of small-molecule Bruton's tyrosine
kinase (BTK) agents is the presence of clinically acquired resistance, which remains a major …

It is considered a significant challenge to understand the neuronal cell death mechanisms
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …

A simplified synthetic method yielded diverse 2-aminobenzothiazole variants through
sulfonylation and amino group alkylation. Extensive characterization via X-ray diffraction …

New hydrazones were synthesized by employing a convergent synthetic methodology
involving condensation of N-alkyl 5-chloroisatins with hydrazone derived from 2 …

Clinical disease milestones (literally a stone functioning as a milepost in ancient Rome; in
medical sciences, a significant event or stage in disease progression) are clinically relevant …

Nondopaminergic neurotransmitters such as adenosine, norepinephrine, serotonin,
glutamate, and acetylcholine are all involved in Parkinson's disease (PD) and promote its …

Covalent inhibitors have been a rapidly growing field in drug discovery due to their
therapeutic potential and unique advantages in cancer therapy. As opposed to noncovalent …