The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Recent rapid progress in the field of mechanobiology has been driven by novel emerging
tools and methodologies and growing interest from different scientific disciplines. Specific …

Mechanosensitive ion channels convert external mechanical stimuli into electrochemical
signals for critical processes including touch sensation, balance, and cardiovascular …

Cell migration is a critical process for diverse (patho) physiological phenomena. Intriguingly,
cell migration through physically confined spaces can persist even when typical hallmarks of …

The TMEM63 family proteins (A, B, and C), calcium-permeable channels in animals that are
preferentially activated by hypo-osmolality, have been implicated in various physiological …

▪ Abstract Physical forces of gravity, hemodynamic stresses, and movement play a critical
role in tissue development. Yet, little is known about how cells convert these mechanical …

The simplest cell-like structure, the lipid bilayer vesicle, can respond to mechanical
deformation by elastic membrane dilation/thinning and curvature changes. When a protein is …

ALL cellular organisms respond to vibration, touch, gravity or changes in osmolarity,
although the molecules on which such mechanosensations depend are unknown …

While mechanobiological processes employ diverse mechanisms, at their heart are force-
induced perturbations in the structure and dynamics of molecules capable of triggering …

Of Aristotle's five senses, we know that sight, smell and much of taste are initiated by ligands
binding to G-protein-coupled receptors; however, the mechanical sensations of touch and …