Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
Transcription factors and 3D genome conformation in cell-fate decisions
How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …
response to environmental cues results in the activation of transcription factors that …
[HTML][HTML] Chromatin architecture reorganization during stem cell differentiation
Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …
Although dynamic chromatin structures have been identified in the genome, the full scope of …
The role of chromatin loop extrusion in antibody diversification
Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …
between convergently oriented CTCF-binding elements. Recent studies indicate that …
Molecular basis and biological function of variability in spatial genome organization
EH Finn, T Misteli - Science, 2019 - science.org
BACKGROUND The eukaryotic genome is hierarchically organized in the cell nucleus into
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …
Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice
AJ Murphy, LE Macdonald, S Stevens… - Proceedings of the …, 2014 - National Acad Sciences
Mice genetically engineered to be humanized for their Ig genes allow for human antibody
responses within a mouse background (HumAb mice), providing a valuable platform for the …
responses within a mouse background (HumAb mice), providing a valuable platform for the …
[HTML][HTML] Genome-wide maps of nuclear lamina interactions in single human cells
Mammalian interphase chromosomes interact with the nuclear lamina (NL) through
hundreds of large lamina-associated domains (LADs). We report a method to map NL …
hundreds of large lamina-associated domains (LADs). We report a method to map NL …
The nuclear lamins: flexibility in function
B Burke, CL Stewart - Nature reviews Molecular cell biology, 2013 - nature.com
The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …
A decade of 3C technologies: insights into nuclear organization
Over the past 10 years, the development of chromosome conformation capture (3C)
technology and the subsequent genomic variants thereof have enabled the analysis of …
technology and the subsequent genomic variants thereof have enabled the analysis of …
DNA hypomethylation in cancer cells
M Ehrlich - Epigenomics, 2009 - Taylor & Francis
DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …
However, for several decades after its independent discovery by two laboratories in 1983, it …