Timing of lifespan influences on brain and cognition

KB Walhovd, M Lövden, AM Fjell - Trends in cognitive sciences, 2023 - cell.com
Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - Nature, 2022 - nature.com
There is strong evidence of brain-related abnormalities in COVID-19,,,,,,,,,,,–. However, it
remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder …

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

YE Tian, V Cropley, AB Maier, NT Lautenschlager… - Nature medicine, 2023 - nature.com
Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

[HTML][HTML] The'middle-aging'brain

S Dohm-Hansen, JA English, A Lavelle… - Trends in …, 2024 - cell.com
Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Brain imaging before and after COVID-19 in UK Biobank

G Douaud, S Lee, F Alfaro-Almagro, C Arthofer… - MedRxiv, 2021 - medrxiv.org
There is strong evidence for brain-related pathologies in COVID-19, some of which could be
a consequence of viral neurotropism, or of neuroinflammation following viral infection. Most …

Mind the gap: Performance metric evaluation in brain‐age prediction

AMG de Lange, M Anatürk, J Rokicki… - Human Brain …, 2022 - Wiley Online Library
Estimating age based on neuroimaging‐derived data has become a popular approach to
developing markers for brain integrity and health. While a variety of machine‐learning …

[HTML][HTML] Deep neural networks learn general and clinically relevant representations of the ageing brain

EH Leonardsen, H Peng, T Kaufmann, I Agartz… - NeuroImage, 2022 - Elsevier
The discrepancy between chronological age and the apparent age of the brain based on
neuroimaging data—the brain age delta—has emerged as a reliable marker of brain health …

Brain-age prediction: A systematic comparison of machine learning workflows

S More, G Antonopoulos, F Hoffstaedter, J Caspers… - NeuroImage, 2023 - Elsevier
The difference between age predicted using anatomical brain scans and chronological age,
ie, the brain-age delta, provides a proxy for atypical aging. Various data representations and …

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

C Constantinides, LKM Han, C Alloza… - Molecular …, 2023 - nature.com
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments,
age-related chronic disease, and premature mortality. We investigated evidence for …

The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease

J Manuello, J Min, P McCarthy… - Nature …, 2024 - nature.com
We have previously identified a network of higher-order brain regions particularly vulnerable
to the ageing process, schizophrenia and Alzheimer's disease. However, it remains …