Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications

J Zielonka, J Joseph, A Sikora, M Hardy… - Chemical …, 2017 - ACS Publications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Large Stokes shift benzothiazolium cyanine dyes with improved intramolecular charge transfer (ICT) for cell imaging applications

CS Abeywickrama - Chemical Communications, 2022 - pubs.rsc.org
Intramolecular Charge Transfer (ICT) is a crucial photophysical phenomenon that can be
used to improve the Stokes' shift in fluorescent dyes. The introduction of molecular …

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

A Hamacher-Brady, NR Brady - Cellular and molecular life sciences, 2016 - Springer
Mitochondria are an essential source of ATP for cellular function, but when damaged,
mitochondria generate a plethora of stress signals, which lead to cellular dysfunction and …

[HTML][HTML] Using flow cytometry for mitochondrial assays

L de Brito Monteiro, GG Davanzo, CF de Aguiar… - MethodsX, 2020 - Elsevier
The understanding of how different cell types adapt their metabolism in the face of
challenges has been attracting the attention of researchers for many years. Recently …

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

SW Perry, JP Norman, J Barbieri, EB Brown… - …, 2011 - Taylor & Francis
Fluorescent probes for monitoring mitochondrial membrane potential are frequently used for
assessing mitochondrial function, particularly in the context of cell fate determination in …

[HTML][HTML] Call to action to properly utilize electron microscopy to measure organelles to monitor disease

K Neikirk, EG Lopez, AG Marshall, A Alghanem… - European Journal of …, 2023 - Elsevier
This review provides an overview of the current methods for quantifying mitochondrial
ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling …

Ce3+ Ions Determine Redox-Dependent Anti-apoptotic Effect of Cerium Oxide Nanoparticles

I Celardo, M De Nicola, C Mandoli, JZ Pedersen… - ACS …, 2011 - ACS Publications
Antioxidant therapy is the novel frontier to prevent and treat an impressive series of severe
human diseases, and the search for adequate antioxidant drugs is fervent. Cerium oxide …

Efficacy of MitoTracker Green™ and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues

W Pendergrass, N Wolf, M Poot - … Part A: the journal of the …, 2004 - Wiley Online Library
Abstract Background Chloromethyl‐X‐rosamine (CMXRos) and MitoTracker Green (MTG)
have proved to be useful dyes with which to measure mitochondrial function. CMXRos is a …

[HTML][HTML] Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils

N Vorobjeva, I Galkin, O Pletjushkina… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Neutrophils release neutrophil extracellular traps (NETs) in response to numerous
pathogenic microbes as the last suicidal resource (NETosis) in the fight against infection …

Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 …

YC Hseu, CW Chou, KJS Kumar, KT Fu… - Food and Chemical …, 2012 - Elsevier
UV radiation from the sun is a potent environmental risk factor in the pathogenesis of skin
damage. Much of the skin damage caused by ultraviolet A (UVA) irradiation from the sun is …