Bioenergetics, mitochondrial dysfunction, and oxidative stress in the pathophysiology of septic encephalopathy

FA Bozza, JC D'Avila, C Ritter, R Sonneville… - Shock, 2013 - journals.lww.com
Sepsis is a major cause of mortality and morbidity in intensive care units. Acute and long-
term brain dysfunctions have been demonstrated both in experimental models and septic …

Metabolic resuscitation strategies to prevent organ dysfunction in sepsis

VA Reitsema, BS Star, VD de Jager… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Sepsis is the main cause of death among patients admitted to the intensive
care unit. As current treatment is limited to antimicrobial therapy and supportive care …

Biological activities of sanguisorba minor l. extracts ñ in vitro and in vivo evaluations

N Ćirović, A Barjaktarevic, M Ninkovic, R Bauer… - 2021 - scidar.kg.ac.rs
© 2020 Polish Pharmaceutical Society. All rights reserved. The literature data about
Sanguisorba minor L. subsp. muricata Briq.(fam. Rosaceae) are limited. It has been used in …

Experimental treatments for mitochondrial dysfunction in sepsis: A narrative review

G Zheng, J Lyu, J Huang, D Xiang, M Xie… - Journal of Research in …, 2015 - journals.lww.com
Sepsis is a systemic inflammatory response to infection. Sepsis, which can lead to severe
sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of …

Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss

CH Yang, MC Kao, PC Shih, KY Li, PS Tsai… - Journal of Surgical …, 2015 - Elsevier
Background Systemic inflammation and oxidative stress are crucial in mediating blood-brain
barrier (BBB) integrity loss during sepsis. Simvastatin possess potent anti-inflammation and …

Sepsis in the central nervous system and antioxidant strategies with nacetylcysteine, vitamins and statins

A Valnier Steckert, A Alves de Castro… - Current …, 2014 - ingentaconnect.com
Sepsis is the complex syndrome characterized by an imbalance between proinflammatory
and antiinflammatory response to infection. The brain may be affected during the sepsis, and …

[HTML][HTML] Acute ethanol exposure disrupts actin cytoskeleton and generates reactive oxygen species in c6 cells

SO Loureiro, L Heimfarth, K Reis, L Wild, C Andrade… - Toxicology in vitro, 2011 - Elsevier
Central nervous system dysfunctions are among the most significant effects of exposure to
ethanol and the glial cells that play an important role in maintaining neuronal function, are …

iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats

NV da Cunha, FNC Lopes, C Panis… - Clinical and …, 2017 - Taylor & Francis
It has been suggested that nitric oxide (NO) from iNOS source is involved in inflammation
and oxidative stress, and hypertension in obese subjects involves an inflammatory process …

[HTML][HTML] Platonin preserves blood–brain barrier integrity in septic rats

CT Yeh, MC Kao, CH Chen, CJ Huang - Acta Anaesthesiologica Taiwanica, 2015 - Elsevier
Objectives Platonin possesses potent anti-inflammatory and antioxidative capacities.
Because systemic inflammation and oxidative stress are crucial in mediating sepsis-induced …

The Dose-Dependent Immunoregulatory Effects of the Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester in Rats with Sub-Acute Peritonitis

CC Hsiao, CH Lee, LY Tsao, HC Lo - 2012 - journals.plos.org
Background Chronic inflammation accompanied by arginine deficiency, immune
dysfunction, and excess nitric oxide (NO) production is a clinical condition found in patients …