[HTML][HTML] New perspectives of taxifolin in neurodegenerative diseases

R Yang, X Yang, F Zhang - Current Neuropharmacology, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
cerebral amyloid angiopathy (CAA), and Huntington's disease (HD) are characterized by …

Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury

Z Hu, L Xuan, T Wu, N Jiang, X Liu, J Chang… - International …, 2023 - Elsevier
Spinal cord injury (SCI) is a severe injury characterized by neuroinflammation and oxidative
stress. Taxifolin is exhibits anti-inflammatory and antioxidative activities in neurologic …

Taxifolin‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid‐induced osteonecrosis of the femoral head

H Jiang, C Lin, T Cai, L Jiang, C Lou, S Lin… - Phytotherapy …, 2024 - Wiley Online Library
Glucocorticoid‐induced osteonecrosis of the femoral head (GIONFH) is the main
complication secondary to long‐term or excessive use of glucocorticoids (GCs). Taxifolin …

Taxifolin reduces blood pressure via improvement of vascular function and mitigating the vascular inflammatory response in spontaneously hypertensive rats

S Liskova, S Cacanyiova, M Cebova… - International Journal of …, 2023 - mdpi.com
The effect of a 10-day-long treatment with taxifolin (TAX, 20 mg/kg/day po) was investigated
on spontaneously hypertensive rats (SHRs) with a focus on the vascular functions of isolated …

Hepatoprotective Effects of Flavonoids against Benzo [a] Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways

M Kim, SC Jee, JS Sung - Antioxidants, 2024 - mdpi.com
Benzo [a] pyrene (B [a] P), a highly carcinogenic polycyclic aromatic hydrocarbon primarily
formed during incomplete organic matter combustion, undergoes a series of hepatic …

Protective effects of arbutin against doxorubicin-induced cardiac damage

O Birdal, I Ferah Okkay, U Okkay, C Bayram… - Molecular Biology …, 2024 - Springer
Background Doxorubicin is an effective antineoplastic agent but has limited clinical
application because of its cumulative toxicities, including cardiotoxicity. Cardiotoxicity …

[HTML][HTML] Hepatoprotective effect of taxifolin on cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in mice: Involvement of Nrf2/HO-1 signaling

OY Althunibat, MH Abukhalil, MM Jghef… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
Taxifolin (TA) is a natural flavonoid found in many foods and medicinal plants with well-
documented antioxidant and anti-inflammatory properties. Cyclophosphamide (CP) is an …

[HTML][HTML] Korean red pine (Pinus densiflora) bark extract attenuates Aβ-induced cognitive impairment by regulating cholinergic dysfunction and neuroinflammation

MJ Go, JM Kim, JY Kang, SK Park, CJ Lee… - … of Microbiology and …, 2022 - ncbi.nlm.nih.gov
In this study, we investigated the anti-amnesic effect of Korean red pine (Pinus densiflora)
bark extract (KRPBE) against amyloid beta 1-42 (Aβ 1-42)-induced neurotoxicity. We found …

Therapeutic Effect of Levetiracetam Against Thioacetamide-Induced Hepatic Encephalopathy Through Inhibition of Oxidative Stress and Downregulation of NF-κB …

K Amirshahrokhi, M Imani - Inflammation, 2024 - Springer
Hepatic encephalopathy (HE) is a serious brain disorder which associated with neurological
and psychiatric manifestations. Oxidative stress and neuroinflammation and apoptosis play …

CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy

A Jhawer, G Frampton, SM Bhattarai, S DeMorrow… - Metabolic Brain …, 2025 - Springer
Acute liver failure results from severe hepatic injury and can lead to neurological dysfunction
known as hepatic encephalopathy (HE). Thrombospondin-1 can contribute to HE by …