Stem cell‐based cell therapy in neurological diseases: a review

SU Kim, J De Vellis - Journal of neuroscience research, 2009 - Wiley Online Library
Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …

Multipotent progenitor cells in the adult dentate gyrus

FH Gage, G Kempermann, TD Palmer… - Journal of …, 1998 - Wiley Online Library
Neurogenesis persists in the adult dentate gyrus of rodents throughout the life of the
organism. The factors regulating proliferation, survival, migration, and differentiation of …

Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat

K Jin, M Minami, JQ Lan, XO Mao… - Proceedings of the …, 2001 - National Acad Sciences
Because neurogenesis persists in the adult mammalian brain and can be regulated by
physiological and pathological events, we investigated its possible involvement in the …

Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain

VG Kukekov, ED Laywell, O Suslov, K Davies… - Experimental …, 1999 - Elsevier
Recentin vitrostudies have shown that the periventricular subependymal zone (SEZ) of the
rodent brain is capable ofde novogeneration of neurons and glia. There is less information …

Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

JD Flax, S Aurora, C Yang, C Simonin, AM Wills… - Nature …, 1998 - nature.com
Stable clones of neural stem cells (NSCs) have been isolated from the human fetal
telencephalon. These self-renewing clones give rise to all fundamental neural lineages in …

Young neurons from medial ganglionic eminence disperse in adult and embryonic brain

H Wichterle, JM Garcia-Verdugo, DG Herrera… - Nature …, 1999 - nature.com
In this study, we identified neuronal precursors that can disperse through adult mammalian
brain tissue. Transplanted neuronal precursors from embryonic medial ganglionic eminence …

Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic …

AL Vescovi, EA Parati, A Gritti, P Poulin, M Ferrario… - Experimental …, 1999 - Elsevier
Stem cells that can give rise to neurons, astroglia, and oligodendroglia have been found in
the developing and adult central nervous system (CNS) of rodents. Yet, their existence …

Delivery of peptide and protein drugs over the blood–brain barrier

I Brasnjevic, HWM Steinbusch, C Schmitz… - Progress in …, 2009 - Elsevier
Peptide and protein (P/P) drugs have been identified as showing great promises for the
treatment of various neurodegenerative diseases. A major challenge in this regard …

“Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain

BD Yandava, LL Billinghurst… - Proceedings of the …, 1999 - National Acad Sciences
Many diseases of the central nervous system (CNS), particularly those of genetic, metabolic,
or infectious/inflammatory etiology, are characterized by “global” neural degeneration or …

Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury

P Riess, C Zhang, KE Saatman, HL Laurer… - …, 2002 - journals.lww.com
OBJECTIVE: Using the neural stem cell (NSC) clone C17. 2, we evaluated the ability of
transplanted murine NSCs to attenuate cognitive and neurological motor deficits after …