The molecular basis of endothelial cell plasticity
E Dejana, KK Hirschi, M Simons - Nature communications, 2017 - nature.com
The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial
cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also …
cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also …
RUNX transcription factors: orchestrators of development
ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
including basic cellular and developmental processes, stem cell biology and tumorigenesis …
Runx transcription factors in the development and function of the definitive hematopoietic system
M de Bruijn, E Dzierzak - Blood, The Journal of the American …, 2017 - ashpublications.org
The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved
and encode proteins involved in a variety of cell lineages, including blood and blood-related …
and encode proteins involved in a variety of cell lineages, including blood and blood-related …
Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system
B Song, Y Fan, W He, D Zhu, X Niu… - Stem cells and …, 2015 - liebertpub.com
The generation of beta-thalassemia (β-Thal) patient-specific induced pluripotent stem cells
(iPSCs), subsequent homologous recombination-based gene correction of disease-causing …
(iPSCs), subsequent homologous recombination-based gene correction of disease-causing …
Specification and function of hemogenic endothelium during embryogenesis
E Gritz, KK Hirschi - Cellular and Molecular Life Sciences, 2016 - Springer
Hemogenic endothelium is a specialized subset of developing vascular endothelium that
acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and …
acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and …
Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver
One day prior to mass emergence of haematopoietic stem cells (HSCs) in the foetal liver at
E12. 5, the embryo contains only a few definitive HSCs. It is thought that the burst of HSC …
E12. 5, the embryo contains only a few definitive HSCs. It is thought that the burst of HSC …
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells
Pluripotent stem cells (PSCs) represent an alternative hematopoietic stem cell (HSC) source
for treating hematopoietic disease. The limited engraftment of human PSC–derived (hPSC …
for treating hematopoietic disease. The limited engraftment of human PSC–derived (hPSC …
RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM)
B Schlegelberger, PG Heller - Seminars in hematology, 2017 - Elsevier
In this review, we discuss disease-causing alterations of RUNT-related transcription factor 1
(RUNX1), a master regulator of hematopoietic differentiation. Familial platelet disorder with …
(RUNX1), a master regulator of hematopoietic differentiation. Familial platelet disorder with …
Understanding hematopoietic stem cell development through functional correlation of their proliferative status with the intra-aortic cluster architecture
During development, hematopoietic stem cells (HSCs) emerge in the aorta-gonad-
mesonephros (AGM) region through a process of multi-step maturation and expansion …
mesonephros (AGM) region through a process of multi-step maturation and expansion …
Recent advances in developmental hematopoiesis: diving deeper with new technologies
B Weijts, L Yvernogeau, C Robin - Frontiers in Immunology, 2021 - frontiersin.org
The journey of a hematopoietic stem cell (HSC) involves the passage through successive
anatomical sites where HSCs are in direct contact with their surrounding microenvironment …
anatomical sites where HSCs are in direct contact with their surrounding microenvironment …